HDAC 11 | Histone deacetylase 11

Histone deacetylase 11 or HDAC11 as the name suggests is a histone deacetylase enzyme responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) thus giving a tag for epigenetic repression. A nuclear protein HDAC11 controls DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression. HDAC11 belongs to the histone deacetylase family and is known to play an important role in transcriptional regulation, cell cycle progression and developmental events and acts via the formation of large multiprotein complexes. Activity of HDAC11 is inhibited by a known histone deacetylase inhibitor, trapoxin. This protein is strongly expressed in brain, heart, skeletal muscle, kidney and testis.