HDAC 10 | Histone deacetylase10

Histone deacetylase 10 or HDAC10 as the name suggests is a histone deacetylase enzyme responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) thus giving a tag for epigenetic repression. HDAC10 belongs to the histone deacetylase family and type 2 subfamily and is known to play an important role in transcriptional regulation, cell cycle progression and developmental events and acts via the formation of large multiprotein complexes. A nuclear protein HDAC10 is however excluded from the nucleoli. This protein is ubiquitously expressed in most of the tissues with high expression in liver, spleen, pancreas and kidney.