DNMT3a | DNA Methyl transferase 3a

DNMT3A also known as DNA (cytosine-5)-methyltransferase 3A is a nuclear protein belonging to the C5-methyltransferase family with an ADD-type zinc finger and a PWWP domain. This nuclear protein localizes to euchromatin and is essential for genome wide de novo methylation and is also essential for development. DNA methylation is coordinated with methylation of histones. DNMT3A associates with HDAC1 through its ADD-type zinc-finger. It binds to the ZNF238 transcriptional repressor and is also known to interact with other DNA methyltransferases like DNMT1 and DNMT3B.