HDAC 5 | Histone deacetylase 5

HDAC5 also known as Histone deacetylase 5 is an enzyme involved in the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) thus giving a tag for epigenetic repression. HDAC5 plays an important role in transcriptional regulation, cell cycle progression and developmental events. Like other histone deacetylases HDAC5 which belongs to the histone deacetylase family and type 2 subfamily is known to form large multiprotein complexes. It is involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. This nuclear protein is known to shuttle between the nucleus and the cytoplasm during myocyte differentiation, thus allowing the expression of myocyte enhancer factors. It is ubiquitously expressed in most of the tissues.